alcohol drinking

Alcohol Drinking is becoming Fashion in INDIA which is a matter of concern. Drinkers consider non drinkers as
backward  & of past century. Many of them say they are social drinkers & drink only at parties, but once a drinker is always a drinker. People who take alcohol are unaware of the fact that it could lead them to severe Neurodegenerative Disorders such as Parkinsonism & Dementia.

The enzyme responsible for pleasure feeling that comes after drinking alcohol is aldehyde dehydrogenase.
This enzyme metabolises the alcohol in the liver & thus produses the pleasure feeling that comes after taking alcohol. However this enzyme is highly lipophilic , therefore it crosses the blood - brain barrier . After reaching the blood- brain barrier it metabolises  Dopamine( a neurotransmitter), due to its structural similarity with mono amine oxidase. The metabolism of Dopamine results in its depletion from the basal ganglia of our brain. All these factors results in increased ri metabolism of alcohol  thatgidity in the body because the function of Dopamine is to bring relaxation of body muscles. Ultimately it results in Parkinsons Disease. 
Another mechanism for this disease would be that tiommetabolism of alcohol results in free radical formation, which coukinsons dld cause damage to nuclei present in basal ganglia & result in Parkinsons Disease.


Alcohol Drinking  reduces the firing power of neurons & thus decrease the number of synapses formed. Probably this is responsible for Dementia.


Therefore if u want to stay healthy then keep away from alcohol. For persons who find it difficult to leave alcohol , a drug named Disulfiram is available. It comes under the brand name of antadict 250 mg tablet ( internationally marketed as antabuse)